The first Crossroads Guitar Festival was held at the Cotton Bowl from June 4 to June 6, 2004. The festivals benefited the Crossroads Centre founded by Eric Clapton, which is a drug treatment center located in Antigua. Featured performers included:

Eric Clapton
Johnny A.
Jeff Beck
Vishwa Mohan Bhatt
Ron Block
Booker T. & the M.G.’s
Doyle Bramhall II
J. J. Cale
Larry Carlton
Robert Cray
Sheryl Crow
Bo Diddley
Jerry Douglas
David Honeyboy Edwards
Vince Gill
Buddy Guy
David Hidalgo
Zakir Hussain
Eric Johnson
B. B. King
Sonny Landreth
Jonny Lang
Robert Lockwood, Jr.
John Mayer
John McLaughlin
Pat Metheny
Robert Randolph
Duke Robillard
Carlos Santana
Neal Schon
Styx
Hubert Sumlin
James Taylor
Dan Tyminski
Steve Vai
Jimmie Vaughan
Joe Walsh
ZZ Top
David Johansen

The Cotton Bowl
3750 Cotton Bowl Plaza
Dallas TX 75210